The 2025 NFL season begins Thursday, September 4, with a full slate of matchups that stretch across four days and feature key division games, playoff hopefuls, and prime-time openers. Week 1 betting lines are already live, giving bettors and analysts a clear view of how oddsmakers are rating each team before a single snap.
From Philadelphia and Los Angeles to Buffalo and Green Bay, the matchups are spread across major markets and evenly matched rosters. Spreads are tight, totals vary by matchup style, and early line movement has been minimal, making this a pivotal window to track public sentiment and lineup news.
Whether it’s the Eagles opening at home against Dallas or the Bills and Ravens meeting in Sunday night’s highest total, every number posted offers insight into expectations. These early lines won’t stay still for long, which is exactly why they’re worth watching now.
Eagles vs. Cowboys on Thursday, September 4 at 8:20 pm
The Eagles are 6.5-point favorites at home with a moneyline of -310, while the Cowboys are listed at +250. The total on FanDuel Sportsbook sits at 46.5, with team totals set at Eagles 26.5 and Cowboys 19.5.
Philadelphia finished last season 14-3 and remains one of the most stable offensive units in the league. With continuity at quarterback, coordinator, and on the line, it’s no surprise to see them favored strongly against a Dallas team trying to regroup after a 7-10 finish.
This line hasn’t moved significantly, which suggests confidence from both the public and books. If the Eagles go up early, the Cowboys may be forced into lower-efficiency passing downs. This is key for in-game totals and drive props.
Chiefs vs. Chargers on Friday, September 5 at 8:00 pm
Kansas City heads to Brazil as a 3-point road favorite, with a moneyline of -162 and the Chargers +136. The total is set at 45.5, while team totals come in at Chiefs 24.5 and Chargers 21.5.
The Chiefs return most of their offensive core after going 15-2. Los Angeles finished 11-6 and added defensive depth in the secondary. These are two of the most explosive play-callers in the AFC, and the line suggests confidence in a clean, efficient game.
Totals haven’t shifted, but injury reports could influence this late in the week. The Chargers have covered well in close home games, but must avoid a slow start to keep pace.
Browns vs. Bengals on Sunday, September 7 at 1:00 pm
Cincinnati enters as a 5.5-point road favorite over Cleveland. The moneyline is Bengals -250, Browns +205, and the total remains at 45.5. The team totals are set at Bengals 26.5 and Browns 20.5.
This AFC North battle typically flies under the radar, but line movement this week suggests growing confidence in Cincinnati’s offense. After a 9-8 season, the Bengals’ quarterback returns healthy and ready, while Cleveland’s offense remains a question mark despite playmaking flashes.
This spread has held, but totals could tick down if the weather becomes a factor. Bettors will also track public lean, especially if Cincinnati gains late-week attention and shifts to -6.
Steelers vs. Jets on Sunday, September 7 at 1:00 pm
Pittsburgh opens as a 3-point favorite at home, with the moneyline at -154, the Jets at +130, and a total of 37.5 – the lowest of Week 1. Team totals reflect this: Steelers 20.5, Jets 17.5.
This is one of the most physical games on the schedule. Pittsburgh returns one of the league’s top front sevens, while New York’s defense quietly finished top five in adjusted third-down rate last season. Offensively, both teams are cautious, making this a prime under candidate.
No line movement has appeared yet, but team total props may shift by Sunday morning if weather or defensive injuries are confirmed.
Packers vs. Lions on Sunday, September 7 at 4:25 pm
Detroit enters Green Bay as a 1.5-point road favorite, with a moneyline of -126, while the Packers are +108. The total is 48.5, the second-highest total of the week. Both teams are currently listed with team totals of 24.5.
This divisional matchup could set the tone for the NFC North. Detroit finished 15 and 2 and remains one of the best second-half scoring teams in the league. Green Bay, despite flying under the radar, was excellent at home in 2024 and returns a healthy offensive core.
Because the spread is under 2, sharp money may move this line quickly if injury reports surface. Otherwise, totals are expected to hold unless heavy public money drives it above 49.
Rams vs. Texans on Sunday, September 7 at 4:25 pm
Los Angeles hosts Houston as a 2.5-point favorite, with a moneyline of -146, while the Texans sit at +124. The total sits at 44.5, with team totals at Rams 23.5 and Texans 20.5.
Both teams are on the upswing, and this line opened tight for good reason. Houston’s youth movement has produced real value, and Los Angeles still holds one of the most efficient passing attacks in the league.
Totals are unlikely to move much before Sunday, but live betting lines could be highly reactive to early turnovers or defensive scores.
Ravens vs. Bills on Sunday, September 7 at 8:20 pm
Buffalo is a 1.5-point favorite on the road, with a moneyline of -116. Baltimore is just behind at -102, making this one of the closest lined games of Week 1. The total is 52.5, the highest of the weekend. Team totals are split evenly at 26.5 for both teams.
This feels like a playoff game in September. Both teams have elite quarterback play and are healthy at the skill positions. Defensively, both units can force turnovers and limit big plays, but oddsmakers still expect fireworks.
Line movement has stayed neutral, but the total may hit 53 if betting volume continues upward into Sunday.
Early Line Movement Can Shape Long-Term Angles
Each of these matchups offers more than opening-week excitement. They reflect where the market sees stability, value, and early momentum. The best betting angles in Week 1 often appear before the first whistle, when speculation meets numbers and depth charts meet pressure.
While every game has an edge, these contests stand out because they’re not just competitive; they’re priced tight for a reason. Watching how these lines behave throughout the week is one of the simplest ways to spot misread teams early and gain insight before the broader market catches up.
*Content reflects information available as of 27/08/2025; subject to change.
